timmytim wrote:Say I have a two channel radio and one 6x9 speaker to put in dash

Can I take the radio (+) from channel one and (-) from channel two and hook to speaker? Wondering best way to hook a single speaker up

Generally No. If your Stereo Radio has a separate (+) positive and (-) negative wire for each channel (referred to as a Floating Ground), you will fry it if you try to connect the two channels together.
If, by chance, it has a (+) positive wire for each channel, but only has a single (-) negative wire that it uses for both channels (referred to as a Common Ground), then you can
usually get away with connecting the single (-) negative wire to the (-) negative terminal of the speaker and connecting both (+) positive wires to the positive terminal of the speaker.
Most car stereos made after the early 1980's were the Floating Ground type. In other words, if there are more than a total of three speaker wires coming out of the unit,
Do Not connect any of them together.

I Hope This Helps.